Project title: Luminescent Organic-Inorganic Hybrid Water Soluble Supramolecular Architectured Nanoplaforms for Theranostics
Project manager: dr. Andelescu Adelina-Antonia
Mentor: Dr. Silvestru Anca
Project number: PN-III-P1-1.1-PD-2021-0427
Contract number: PD 21/2022
Proiect acronim: LOISA
Total budget of the project:: 248.072 lei
Co-financing budget: 0 lei
ICT eligible budget: 248.072 lei
Contract period: 24 luni (11.04.2022 – 31.03.2024)
Financing entity: Executive Unit for the Financing of Higher Education, Research, Development and Innovation
Abstract: In the framework of synthesising new advanced functional materials, the scope of the project is to obtain new luminescent organic-inorganic hybrid supramolecular architectured water soluble nanoplatforms (LOISA) carrying luminescent d-block transition metal complexes (TMCs) based on Zn(II) and Pt(II) metal centres with terpyridine (tpy) ligands functionalized with selenium anchors and hydrophilic ancillary ligands (HL). The nanoplatforms are designed to have dual simultaneous function (theranostic agents) combining diagnosis (sensitive emission properties) and treatment (carriers of potential anticancer drugs – TMCs). The research approach is a continuation of the work developed by the project leader (PL) during her PhD. The originality and novelty of the project consist in the use of selenide linkers for a successful obtainment with high yields of LOISA, fructifying the vast knowledge of the Mentor in the field of organochalcogen chemistry. Another key novelty highly useful for future applications in biological fields is the induction of water solubility using hydrophilic ligands.
Objectives: The scope of the project is to obtain new luminescent organic-inorganic hybrid supramolecular architectured water soluble nanoplatforms (LOISA) carrying luminescent d-block transition metal complexes (TMCs) based on Zn(II) and Pt(II) metal centres with terpyridine (tpy) ligands functionalized with selenium anchors and hydrophilic ancillary ligands (HL).
Estimated results: 2 terpyridine-based ligands functionalized with alkyl chains containing selenium; 2 galic acid derivatives functionalized with hydrophilic chains; 2 new TMCs based on Zn(II) metal centre; 2 new TMCs based on Pt(II) metal centre; 1 luminescent water soluble TMC; spherical Au NPs with a particle size between 4 – 10 nm; 2 luminescent hybrid nanoplatforms; 2 LOISA. 3 papers published in journals indexed in Web of Science Core Collection,2 presentations at international scientific conferences and scientific reports.
Articles:
Stage 2
- Andelescu A.A, Candreva A., Popa E., Visan A., Cretu C., La Deda M., Szerb E.I. „Role of the
environment polarity on the photophysical properties of mesogenic hetero-polymetallic complex”,
Molecules 2024, 29, 750. I.F = 4.9 - Popa E., Andelescu A.A.*, Badea V., Svera P., Szerb E.I. „bis(2,6-di(pyridin-2-yl)pyridin-4-yl)-6,6'-
(1,2-diselanediyl)dihexanoate”, Molbank 2024, 2024(1), M1752. I.F = 0.6 (*autor de corespondenta) - Ilies S., Andelescu A., Visan A., Baciu A., Szerb E.I., Manea F. „Ferrocene-containing gallic acid
derivative modified carbon nanotubes electrode for fast and simple simultaneous or selective detection of
cytostatic from aqueous solutions”, Chemosensors 2024, 12, 15. I.F = 4.2 (co-autor) - Cretu C., Andelescu A.A., Silvestru A., Chiș V., Candreva A., La Deda M., Szerb E.I., Symmetry,
aggregation and counterion role in tuning NIR absorbance of a Cu(I) coordination complex. Inorganica
Chimica Acta 2024 .under review – co-autor
Oral presentations at international or national conferences:
Stage 1
- Andelescu A.A., Cretu C., Szerb E.I., Silvestru A.,
Supramolecular architectured water-soluble based on coordination compounds with N-donor ligands
28th International Symposium on Analytical and Environmental Problems, 14-15 November, 2022, Szeged, Hungary.
Stage 2
- Andelescu A.A., Cretu C., Szerb E.I., Silvestru A.,
Water soluble luminescent coordination complexes
4th Young Researchers’ International Conference On Chemistry And Chemical Engineering, 01-03 June, 2023, Debrecen, Hungary
Poster presentation at international or national conferences:
Stage 2:
- Andelescu A.A.,
Hybrid nanoplatforms containing d-block coordination complexes for biological applications
1er Symposium de la Recherche Scientifique francophone en Roumanie, 19-20
December, 2022, Bucharest, Romania
Stage 3:
- Popa E., Cretu C., Szerb E.I, Andelescu A.A.,
„Luminescent studies on lyotropic Zn(II) coordination complexes”, Nanomaterials and Nanoarchitectures II. Composite Materials & their Applications.
NATO ASI Summer School for Students from NATO countries and NATO Partner countries. Congress Center SAS, Smolenice Castle, June 28 th – July 5 th , 2024
Other results:
Dissemination: European Researchers Night, 30 September 2022, Nokia Campus, Timisoara
Reports:
First stage: April-December 2022
Second stage: January-December 2023
Third stage: January-July 2024
Acnowledgements: This work was supported by a grant of the Ministry of Research, Innovation and Digitization, CNCS/CCCDI – UEFISCDI, project number PN-III-P1-1.1-PD-2021-0427, within PNCDI III.
