Project type: Mobility project Romania – Republic of Moldova
Project title: New non-toxic aromatic carboxylate derivatives with role in plant growth regulation: from synthesis and structural investigations to biological tests
Project code: PN-III-P3-CEI-BIM-PM-2016-2017
Constract no.: 24 BM/19.09.2016
Project acronim: CarePlant
Contracting Unit: UEFISCDI (Executive Unity for Financing the Superior Education, Research, Development and Innovation)
Contracted Unit: Institute of Chemistry Timisoara of Romanian Academy
Period: 16 months (September 2016-December 2017)
Total value Romania: 16480 Lei
Amount in 2016 Romania: 4360 Lei
Amount in 2017 Romania: 12120 Lei
Project leader from Romania: dr. chim. Manuela CRIȘAN, Institute of Chemistry Timisoara of Romanian Academy
Project leader from Republic of Moldova: dr. chim. Pavlina BOUROȘ, Institute of Applied Physics, Academy of Sciences of Moldova
Project members from Romania:
Institute of Chemistry Timisoara of Romanian Academy – Coordinator
dr. ing. Pleşu Nicoleta
dr. ing. Petric Mihaela
dr. ing. Ţară Lungă-Mihali Milica
West Univestity of timisoara – Partner 1
Conf. dr. ing. habil. Vlase Titus
drd. chim. Budiul Mihaela
The Banat’s University of Agricultural Sciences and Veterinary Medicine “King Michael Ist of Romania” from Timisoara – Partner 2
Prof. dr. univ. Şumălan Radu
drd. ing. Bodnarescu Florin
Prof. dr. univ. Botău Dorica
drd. ing. Simina Alina Georgiana
Project Summary:
Agriculture plays an essential role in the economies of Romania and the Republic of Moldova. Thus, the CarePlant project aims to obtain non-toxic compounds with role in plant growth regulating in order to improve the production of vegetables, which is a priority not only in the two countries, but also throughout the world. The project opens an innovative interdisciplinary approach by involving teams from Romania and the Republic of Moldova with expertise in chemistry, crystallography and biology. All partners contribute their experience in obtaining, characterizing and testing biological new carboxylic aromatic derivatives as plant growth regulators. The new compounds will be characterized by physicochemical (FTIR-ATR, NMR, MS), thermal (TGA / DSC) and structural (X-ray powder and single crystal diffraction) methods in order to establish the structure, determine the intermolecular interactions and the existence of polymorphic forms. In order to complete the experimental investigations and to obtain complex information about the analyzed molecular system, quantum chemistry calculations will be performed. The effect of the compounds on the rooting of the vegetable seedlings, the germination capacity of the seeds and the plant growth regulation in correlation with photosynthesis and cellular respiration will be studied. The originality of the project consists in obtaining of new compounds with dual biological activity, based on non-toxic components or natural metabolites and testing them as new plant growth regulators.
Publications in ISI journals:
- M. Crisan, L. Halip, P. Bourosh, S.A. Chicu, Y. Chumakov, Synthesis, structure and toxicity evaluation of ethanolamine nitro/chloronitrobenzoates: a combined experimental and theoretical study, Chemistry Central Journal, 2017, 11(1), 129-139. (F.I. = 2.284)
- M. Crisan, G. Vlase, E. I. Szerb, T. Vlase, Thermal and kinetics studies of primary, secondary and tertiary alkanolammonium salts of 4-nitrobenzoic acid, J. Therm. Anal. Calorim., 2018, 132(2), 1409-1418. (F.I. = 2.471)
- M. Crisan, G. Vlase, N. Plesu, M. Petric, L. Croitor, V. Kravtsov, Y. Chumakov, P. Bouros, T. Vlase, Ethylethanolammonium 4-nitrobenzoate: Synthesis, structural characterization, thermal analysis, non-isothermal kinetic investigations and corrosion inhibitor efficiency, J. Therm. Anal. Calorim., 2018, 134(1), 343-352. (F.I. = 2.471)
Publications in journals included in other internationally recognized databases (BDI):
- Roxana Luca, Manuela Crisan, Dorica Botau, The role of nitrobenzoic acid derivatives on callus induction and plant regeneration in Paulownia shan tong, Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca -Veterinary Medicine, 73(2), 2016, 178-182, code CNCSIS 863 (rev B+, BDI)
- Alina Simina, Manuela Crisan, Sorin Ciulca, Dorica Botau, The influence of Monoethanolamine 4-aminobenzoate on callus growth of Momordica charantia L., Journal of Horticulture, Forestry and Biotechnology, 2017, 21(1), 174-178, code CNCSIS 136 (rev B+, BDI)
Conference participation:
1. Luca R., Crisan M., Botau D., The Role of Nitrobenzoic Acid Derivatives on Callus Induction and Plant Regeneration in Paulownia Shan Tong, 15th International Symposium “Prospects For The 3rd Millennium Agriculture”, Cluj-Napoca, Romania, 29 September-1 October 2016.
2. Crisan M., Bourosh P., Chumakov Y., Solid forms of dimethylethanolamine salt of 2-chloro-4-nitrobenzoate: structural characterization, 8th International Conference Materials Science and Condensed Matter Physics (MSCMP2016), Chişinău, 12-16 September 2016, p.176
3. Manuela Crișan, Mihaela Petric, Nicoleta Pleșu, Elena Melnic, Lilia Croitor, Victor Kravtsov, Pavlina Bourosh, Supramolecular architectures of ionic co-crystals based on 4-nitrobezoic acid and alkanolamines, The 6th International Conference Ecological & Environmental Chemistry, 2-3 March 2017, Chișinău, Republic of Moldova, Abstract Book p.79.
4. Manuela Crișan, Massimo Maffei, Paulina Bourosh, Radu Șumalan, Florin Bodnărescu, Ethanolammonium salts of substituted benzoic acids as alternative plant growth regulators, The 6th International Conference Ecological & Environmental Chemistry, 2-3 March 2017, Chișinău, Republic of Moldova, Abstract Book p.151.
5. Nicoleta Pleșu, Manuela Crișan, Mihaela Petric, Lilia croitor, Victor Kravtsov, Paulina Bourosh, Structural and conductance studies of ethylethanolamine 4-nitrobenzoate, New trends and strategies in the chemistry of advanced materials with relevance in biological systems, technique and environmental protection, 9th edition, 9-10 June 2017, Timișoara, p.63.
6. Manuela Crișan, Mihaela Petric, Lilia Croitor, Pavlina Bourosh, Supramolecular architectures of isomeric methylethanolamine chloronitrobenzoates, New trends and strategies in the chemistry of advanced materials with relevance in biological systems, technique and environmental protection, 9th edition, 9-10 June 2017, Timișoara, p.66.
7. Manuela Crișan, Titus Vlase, Paulina Bourosh, Yurii Chumakov, Elisabeta I. Szerb, Mihaela Petric, An investigation into the crystal formation and thermal induced processes of dimethylethanolammonium 4-nitrobenzoate, 4th Central and Eastern European Conference on Thermal Analysis and Calorimetry, 28-31 August 2017, Chișinău, Republic of Moldova, Book of Abstract p.494.
8. Manuela Crișan, Nicoleta Pleșu, Titus Vlase, Mihaela Petric, Lilia Croitor, Victor Kravtsov, Paulina Bourosh, An investigation into the crystal formation and thermal induced processes of dimethylethanolammonium 4-nitrobenzoate, 4th Central and Eastern European Conference on Thermal Analysis and Calorimetry, 28-31 August 2017, Chișinău, Republica Moldova, Book of Abstract p.495.
9. Manuela Crișan, Mihaela Petric, Nicoleta Pleșu, Elena Melnic, Lilia Croitor, Victor Kravtsov, Paulina Bourosh, Structural study of protic triethanolammonium ionic liquid based on 4-nitrobenzoic acid and their Ni(II) complex, Zilele Academice Ieșene – Progrese în știința compușilor organici și macromoleculari, Macro Iași 2017, 5-6 October 2017, Iași, p. 43.
10. Manuela Crisan, Mihaela Petric, Pavlina Bourosh, Lilia Croitor, New alkanolamines salts of p-aminobenzoic acid: synthesis and structural analysis, New trends and strategies in the chemistry of advanced materials with relevance in biological systems, technique and environmental protection, 11th edition, 28-29 June 2018, Timișoara, p. 71.
11. Crisan M., Petric M., Bourosh P., Croitor L, Supramolecular assemblies via hydrogen bond interactions of new triethanolammonium chloronitrobenzoates. 9th International Conference on Materials Science and Condenced Matter Physics MSCMP 2018, 25-28 September 2018. Chișinău, Abstracts. DSCM P14. p. 125 .
Other dissemination of results:
1. Roxana Luca, Manuela Crișan, Dorica Botău, Behaviour of various Paulownia species cultivated in vitro and in vivo, Proceedings of The 9th Edition of EUROINVENT, European Exhibition of Creativity and Innovation, 25-27 May 2017, Iași, RO 113, p. 375. – Diploma and gold medal for the Innovative Projects section
2. Manuela Crisan, Mihaela Petric, Paulina Bouros, Alessandra Forni, Massimo Maffei, Yurii Chumakov, Dorica Botău, Florin Bodnărescu, Radu Sumălan, New plant growth regulators for a sustainable agriculture, Proceedings of the 10th edition of EUROINVENT, European Exhibition of Creativity and Innovation, 17-19 May 2018, Iasi, RO 237, p.498. – Diploma and gold medal for the Innovative Projects section
3. Manuela Crisan, Nicoleta Plesu, Mihaela Petric, Gabriela Vlase, Titus Vlase, Yurii Chumakov, Paulina Bouros, Victor Kravtsov, Lilia Croitor, Development of environmental friendly corrosion inhibitors for iron in NaCl solution, Proceedings of the 10th edition of EUROINVENT, European Exhibition of Creativity and Innovation, 17-19 May 2018, Iasi, RO 238, p.499. – Diploma and silver medal for the Innovative Projects section
4. European Researchers’ Night, 28 September 2018, Nokia Campus, Timisoara
